Rimeporide

Research use only, not for human use.

Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor.

Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor, show promise as potential therapeutic agents for the treatment of heart failure.Heart Failure Discontinued(In Vitro):Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.

Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.

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EMD87580 | EMD-87580

Membrane Transporter/Ion Channel

Sodium Channel

NHE-1

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187870-78-6

333.377

C11H15N3O5S2

>98% (HPLC)

DMSO: 15 mg/mL,50 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )

CC1=CC(=C(C=C1C(=O)NC(=N)N)S(=O)(=O)C)S(=O)(=O)C

N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years