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CNV1014802 hydrochloride

CAS No. 934240-31-0

CNV1014802 hydrochloride( GSK-1014802 hydrochloride | CNV-1014802 hydrochloride | Raxatrigine hydrochloride | Vixotrigine )

Catalog No. M16677 CAS No. 934240-31-0

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CNV1014802 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker.
  • Description
    CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.Pain Phase 2 Clinical.
  • In Vitro
    Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the US Food and Drug Administration in July 2013.
  • In Vivo
    ——
  • Synonyms
    GSK-1014802 hydrochloride | CNV-1014802 hydrochloride | Raxatrigine hydrochloride | Vixotrigine
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    934240-31-0
  • Formula Weight
    350.815
  • Molecular Formula
    C18H20ClFN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    C1CC(NC1C2=CC=C(C=C2)OCC3=CC=CC=C3F)C(=O)N.Cl
  • Chemical Name
    2-Pyrrolidinecarboxamide, 5-[4-[(2-fluorophenyl)methoxy]phenyl]-, hydrochloride (1:1), (2S,5R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9. 2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78. 3. Zakrzewska JM, et al. Lancet Neurol. 2017 Apr;16(4):291-300.
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