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RU-SKI 43 hydrochloride
CAS No. ——
RU-SKI 43 hydrochloride( RU-SKI43 hydrochloride )
Catalog No. M16978 CAS No. ——
A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRU-SKI 43 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
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DescriptionA small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM; specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src; reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.
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In Vitro——
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In Vivo——
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SynonymsRU-SKI43 hydrochloride
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorHedgehog (Hh)
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight423.0117
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Molecular FormulaC22H31ClN2O2S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 51 mg/mL
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SMILES——
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Chemical NameEthanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Petrova E, et al. Nat Chem Biol. 2013 Apr;9(4):247-9.
2. Petrova E, et al. Oncogene. 2015 Jan 8;34(2):263-8.
3. Matevossian A, et al. Mol Cancer. 2015 Apr 1;14:72.
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