SAG hydrochloride (912545-86-9(free base))( —— )

Catalog No. M35280 CAS No. 2095432-58-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

SAG hydrochloride (912545-86-9(free base))
Note

Research use only, not for human use.
Brief Description

SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
Description

SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
In Vitro

——
In Vivo

Animal Model:Pregnant C57BL/6J mice Dosage:15, 17, 20 mg/kg Administration:A single i.p.Result:Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
Synonyms

——
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Hedgehog/Smoothened
Research Area

——
Indication

——

CAS Number

2095432-58-7
Formula Weight

526.52
Molecular Formula

C28H29Cl2N3OS
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 25 mg/mL (47.48 mM; Ultrasonic) DMSO : 21.67 mg/mL (41.16 mM; Ultrasonic )
SMILES

Cl.CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl
Chemical Name

——

1. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.?

Calculator

molnova catalog