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PIAA
CAS No. 851814-28-3
PIAA( —— )
Catalog No. M16191 CAS No. 851814-28-3
PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePIAA
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NoteResearch use only, not for human use.
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Brief DescriptionPIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells.
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DescriptionPIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells; downregulates polyinosine:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a substrate of TBK1/IKKε; augments β-cell-specific proliferation by increasing cAMP levels and mTOR activity via PDE3, improves glucose control and β-cell mass in the STZ-induced diabetic mouse model.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIκB kinase (IKK)
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Research Area——
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Indication——
Chemical Information
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CAS Number851814-28-3
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Formula Weight265.268
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Molecular FormulaC16H11NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C(C=C1)C2=C3C=C(C=CC3=NO2)C=CC(=O)O
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Chemical Name(E)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu J, et al. Sci Rep. 2018 Oct 22;8(1):15587.
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