Mizagliflozin( DSP-3235 | KGA-3235 | GSK-1614235 )

Catalog No. M15544 CAS No. 666843-10-3

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Datasheet

HNMR

HPLC

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Product Name

Mizagliflozin
Note

Research use only, not for human use.
Brief Description

Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2.
Description

Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2; increases stool frequency and loosens stool consistency in phase I study; increases fecal wet weight in a dog model of loperamide-induced constipation and a rat model of low-fiber-diet-induced constipation, similar to lubiprostone.Diabetes Phase 1 Clinical.
In Vitro

——
In Vivo

Animal Model:Male Wistar rats (rat model of low-fiber-diet-induced constipation)Dosage:3, 10, 30 mg/kg Administration:Oral Result:Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation.
Synonyms

DSP-3235 | KGA-3235 | GSK-1614235
Pathway

GPCR/G Protein
Target

SGLT
Recptor

SGLT
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

666843-10-3
Formula Weight

564.68
Molecular Formula

C28H44N4O8
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : ≥ 100 mg/mL (177.09 mM))
SMILES

O=C(N)C(C)(C)CNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(C)=C1
Chemical Name

3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)-2,2-dimethylpropanamide

1. Inoue T, et al. Eur J Pharmacol. 2017 Jul 5;806:25-31.

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