HPI-1

Research use only, not for human use.

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM).

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM); suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression; inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.

GLI antagonist-1 (compound HPI-1) (0-25 μM; 72 h) shows anti-proliferative activity with IC50 values of 29, >25, 20.5 μM for SUM149, MDA-MB-231, SUM159 cells, respectively.GLI antagonist-1 (10 μM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells.GLI antagonist-1 (5, 10, 20 μM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells.Cell Proliferation Assay Cell Line:SUM149, MDA-MB-231, SUM159 cellsConcentration:0-25 μM Incubation Time:72 h Result:Showed anti-proliferative activity with IC50 values of 29, >25, 20.5 μM for SUM149, MDA-MB-231, SUM159 cells, respectively.

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HPI1

GPCR/G Protein

Hedgehog (Hh)

Hedgehog (Hh)

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599150-20-6

463.5

C27H29NO6

>98% (HPLC)

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CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC

1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester

(-20℃)

With Ice Pack

≥ 2 years