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SMANT hydrochloride
CAS No. 1177600-74-6
SMANT hydrochloride( N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride | N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride | N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide | hydrochloride | SMANT HCl )
Catalog No. M27712 CAS No. 1177600-74-6
SMANT hydrochloride is an antagonist of Smoothened accumulation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 35 | In Stock |
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| 25MG | 71 | In Stock |
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| 50MG | 123 | In Stock |
|
| 100MG | 209 | In Stock |
|
| 200MG | 303 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSMANT hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSMANT hydrochloride is an antagonist of Smoothened accumulation.
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DescriptionSMANT hydrochloride is an antagonist of Smoothened accumulation.
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In VitroSMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC50: 1.1 μM).SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay.SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1+/? neonates) induced by Shh.
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In Vivo——
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SynonymsN-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride | N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride | N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide | hydrochloride | SMANT HCl
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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Recptor5-HT
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Research Area——
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Indication——
Chemical Information
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CAS Number1177600-74-6
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Formula Weight375.73
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Molecular FormulaC16H24BrClN2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (221.78 mM)
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SMILESCl.CC1CC(C)CN(CCC(=O)Nc2ccc(Br)cc2)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Torrisi SA, et al. Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade. Front Pharmacol. 2017 Oct 4;8:710.
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