Purmorphamine( Purmorphamine )

Catalog No. M14618 CAS No. 483367-10-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Purmorphamine
Note

Research use only, not for human use.
Brief Description

Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
Description

Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
In Vitro

Purmorphamine (GMP) (1.5 μM, 1 week) can generate embryoid bodies (EBs) from human iPS cells (hiPS2) and hESCs (HSF1).Purmorphamine (GMP) (1.5 μM) converts hPSCs to NKX2-1 positive MGE cells.Purmorphamine (GMP) (2 μM, day 28-35) promotes ventralization of the brain spheroids in differentiation process from hiPSCs. Purmorphamine (GMP) (1 μM) together with retinoic acid (RA, 2 μM) promotes hiPSC differentiation into functional neural tissue, indicated by the expression of neuronal marker β-tubulin III (βT-III).Purmorphamine (GMP) (day5-7) induces hESCs differentiation into dopaminergic (DA) neurons.
In Vivo

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Synonyms

Purmorphamine
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Smoothened
Research Area

Neurological Disease
Indication

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CAS Number

483367-10-8
Formula Weight

520.62
Molecular Formula

C31H32N6O2
Purity

>98% (HPLC)
Solubility

DMSO: 4 mg/mL warmed (7.68 mM)
SMILES

N1(C2CCCCC2)C=NC3=C(NC4=CC=C(N5CCOCC5)C=C4)N=C(OC6=C7C=CC=CC7=CC=C6)N=C13
Chemical Name

9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine

1.Faghihi F, Biomed PharmacOthers, 2012, 3322(12).

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