A-17

CAS No. 505057-98-7

A-17( Hsp90α inhibitor A17 )

Catalog No. M14721 CAS No. 505057-98-7

A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-17
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM.
  • Description
    A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1; inhibits Hsp90(α/β)/p23 interactions and degrading Hsp90 client proteins in cell culture, but not in live mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Hsp90α inhibitor A17
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    505057-98-7
  • Formula Weight
    384.333
  • Molecular Formula
    C15H11F3N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-((4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.
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