BRD50837( BRD 50837 )

Catalog No. M11264 CAS No. 1314295-24-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BRD50837
Note

Research use only, not for human use.
Brief Description

BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM.
Description

BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway.
In Vitro

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In Vivo

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Synonyms

BRD 50837
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Hedgehog (Hh)
Research Area

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Indication

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CAS Number

1314295-24-3
Formula Weight

550.067
Molecular Formula

C26H32ClN3O6S
Purity

>98% (HPLC)
Solubility

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SMILES

CN(S(=O)(C1=CC=C(Cl)C=C1)=O)C[C@H]2[C@H](CN(C(C3=CC=CC(NC(C4CC4)=O)=C3O2)=O)[C@@H](CO)C)C
Chemical Name

N-((2R,3S)-2-(((4-chloro-N-methylphenyl)sulfonamido)methyl)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)cyclopropanecarboxamide

1. Schaefer GI, et al. J Am Chem Soc. 2013 Jul 3;135(26):9675-80.

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