IC 86621( IC86621 )

Catalog No. M14383 CAS No. 404009-40-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

IC 86621
Note

Research use only, not for human use.
Brief Description

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM).
Description

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM); directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions.
In Vitro

IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12.IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis. TApoptosis Analysis Cell Line:CD4+CD45RO- T cells (from six control donors and seven RA patients)Concentration:0 nM, 50 nM, 100 nM Incubation Time:24 h Result:Protected RA (rheumatoid arthritis) T cells from apoptosis.
In Vivo

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Synonyms

IC86621
Pathway

Cell Cycle/DNA Damage
Target

DNA-PK
Recptor

DNA-PK
Research Area

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Indication

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1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64. 2. Allen C, et al. Mol Cancer Res. 2003 Oct;1(12):913-20.

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