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IC 86621
CAS No. 404009-40-1
IC 86621( IC86621 )
Catalog No. M14383 CAS No. 404009-40-1
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 5MG | 30 | In Stock |
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| 10MG | 44 | In Stock |
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| 25MG | 72 | In Stock |
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| 50MG | 104 | In Stock |
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| 100MG | 153 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIC 86621
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NoteResearch use only, not for human use.
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Brief DescriptionIC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM).
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DescriptionIC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM); directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions.
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In VitroIC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12.IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis. TApoptosis Analysis Cell Line:CD4+CD45RO- T cells (from six control donors and seven RA patients)Concentration:0 nM, 50 nM, 100 nM Incubation Time:24 h Result:Protected RA (rheumatoid arthritis) T cells from apoptosis.
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In Vivo——
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SynonymsIC86621
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PathwayCell Cycle/DNA Damage
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TargetDNA-PK
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RecptorDNA-PK
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Research Area——
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Indication——
Chemical Information
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CAS Number404009-40-1
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Formula Weight221.256
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Molecular FormulaC12H15NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C1=CC=C(N2CCOCC2)C=C1O)=O
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Chemical Name1-(2-hydroxy-4-morpholinophenyl)ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64.
2. Allen C, et al. Mol Cancer Res. 2003 Oct;1(12):913-20.
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