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VX-984
CAS No. 1562396-65-9
VX-984( M 9831 | VX984 )
Catalog No. M12228 CAS No. 1562396-65-9
VX-984 (M 9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88±64 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameVX-984
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NoteResearch use only, not for human use.
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Brief DescriptionVX-984 (M 9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88±64 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells.
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DescriptionVX-984 (M 9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88±64 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells, with good selectivity versus other PI3K family members.Solid Tumors Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsM 9831 | VX984
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PathwayCell Cycle/DNA Damage
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TargetDNA-PK
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RecptorDNA-PK
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1562396-65-9
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Formula Weight401.4702
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Molecular FormulaC22H19D2N7O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=NC=C(C=N1)C2=CC(=NC=N2)NCC(C)C3=CC=CC4=C(C=CN=C43)C(=O)N
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Chemical Name8-[(1S)-1-Methyl-2-[(2'-methyl[4,5'-bipyrimidin]-6-yl-4',6'-d2)amino]ethyl]-4-quinolinecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Harnor SJ, et al. ChemMedChem. 2017 Jun 21;12(12):895-900.
2. D. Boucher, R, et al. AACR; Abstract No. 3716.
molnova catalog
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