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GSK-8999
CAS No. 1422355-59-6
GSK-8999( GSK-2578999 )
Catalog No. M11773 CAS No. 1422355-59-6
GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1683 | Get Quote |
|
| 50MG | 3402 | Get Quote |
|
| 100MG | 4680 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK-8999
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor.
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DescriptionGSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively; shows high potency against 57 of 62 isolates demonstrating an improvement over the first generation maturation inhibitor BVM; has a mechanism of action consistent with inhibition of the proteolytic cleavage of CA-SP1.
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In Vitro——
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In Vivo——
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SynonymsGSK-2578999
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1422355-59-6
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Formula Weight776.44
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Molecular FormulaC46H62ClNO7
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C(C)(C)CC(O[C@@H](CC[C@]1(C)[C@@]2([H])CC[C@@]34[H])C(C)(C)[C@]1([H])CC[C@@]2(C)[C@]3(C)CC[C@]5(C(C(NC6(C7=CC=C(Cl)C=C7)CC6)=O)=O)C4=C(C(C)C)C(C5)=O)=O
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Chemical Name(3β)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-N-[1-(4-chlorophenyl)cyclopropyl]-α,21-dioxo-28-norlup-18-ene-17-acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tang J, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2689-2694.
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