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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - Col 003

Col 003

CAS No. 328565-16-8

Col 003( Col003 )

Catalog No. M14076 CAS No. 328565-16-8

Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 61 In Stock
2MG 37 In Stock
5MG 61 In Stock
10MG 104 In Stock
25MG 217 In Stock
50MG 343 In Stock
100MG 531 In Stock
200MG 762 In Stock
500MG 1144 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Col 003
  • Note
    Research use only, not for human use.
  • Brief Description
    Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM.
  • Description
    Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47; competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix.
  • In Vitro
    Western Blot Analysis Cell Line:Wild-type MEFs Concentration:100 μM Incubation Time:After 50 °C or 37 °C for 15 min Result:Affected correctly folded triple helix structures and α,α′-dipyridyl on collagen secretion.
  • In Vivo
    ——
  • Synonyms
    Col003
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    328565-16-8
  • Formula Weight
    257.245
  • Molecular Formula
    C14H11NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (194.37 mM)
  • SMILES
    C1=CC=C(C=C1)CC2=CC(=C(C(=C2)[N+](=O)[O-])O)C=O
  • Chemical Name
    5-benzyl-2-hydroxy-3-nitrobenzaldehyde

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ito S, et al. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
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