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Home - Products - Metabolic Enzyme/Protease - AChE - Zanapezil

Zanapezil

CAS No. 263248-42-6

Zanapezil( TAK-147 | TAK147 )

Catalog No. M13806 CAS No. 263248-42-6

Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Zanapezil
  • Note
    Research use only, not for human use.
  • Brief Description
    Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM.
  • Description
    Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM; ameliorates the passive avoidance deficit induced by diazepam in animal models at 1-3 mg/kg, ameliorates the impairment of DMTP performance induced by scopolamine without affecting the general behavior of the rats.Alzheimer Disease Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TAK-147 | TAK147
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    AChE
  • Recptor
    AChE
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    263248-42-6
  • Formula Weight
    492.616
  • Molecular Formula
    C29H36N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CCNC2=C(C1)C=CC(=C2)C(=O)CCC3CCN(CC3)CC4=CC=CC=C4.C(=CC(=O)O)C(=O)O
  • Chemical Name
    3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1- benzazepin-8-yl)-1-propanone fumarate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hatip-Al-Khatib I, et al. Br J Pharmacol. 2005 Aug;145(8):1035-44. 2. Hirai K, et al. J Pharmacol Exp Ther. 1997 Mar;280(3):1261-9. 3. Miyamoto M, et al. J Pharmacol Exp Ther. 1996 Jun;277(3):1292-304. 4. Ishihara Y, et al. J Med Chem. 1994 Jul 22;37(15):2292-9.
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