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TAK-802 hydrochloride
CAS No. 263248-36-8
TAK-802 hydrochloride( TAK 802 | TAK802 )
Catalog No. M13805 CAS No. 263248-36-8
A potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTAK-802 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition.
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DescriptionA potent acetylcholinesterase (AChE) inhibitor with IC50 of 1.3 nM; exhibits high selectivity for acetylcholinesterase inhibition over butyrylcholinesterase inhibition; increases rhythmic bladder contractions in Guinea pigs and rats without affecting the basal intravesical pressure.Other Indication Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTAK 802 | TAK802
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number263248-36-8
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Formula Weight456.986
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Molecular FormulaC26H30ClFN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ishichi Y, et al. Bioorg Med Chem. 2005 Mar 15;13(6):1901-11.
2. Nagabukuro H, et al. Eur J Pharmacol. 2004 Feb 6;485(1-3):299-305.
3. Nagabukuro H, et al. Eur J Pharmacol. 2004 Jun 28;494(2-3):225-32.
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