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MAP4K4-IN-37
CAS No. 2089334-01-8
MAP4K4-IN-37( —— )
Catalog No. M13270 CAS No. 2089334-01-8
MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMAP4K4-IN-37
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NoteResearch use only, not for human use.
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Brief DescriptionMAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.
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DescriptionMAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetMAP4K
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RecptorMAP4K
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Research Area——
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Indication——
Chemical Information
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CAS Number2089334-01-8
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Formula Weight382.844
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Molecular FormulaC21H19ClN2O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-{4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]phenoxy}-2-methylpropanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dow RL, et al. J Med Chem. 2018 Apr 12;61(7):3114-3125.
molnova catalog
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GNE-220
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PF-06260933
PF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.
