DMX-5804( DMX5804 | DMX 5804 )

Catalog No. M13644 CAS No. 2306178-56-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DMX-5804
Note

Research use only, not for human use.
Brief Description

DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM.
Description

DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM; displays >100-fold selectivity over GCK/MAP4K2, GLK/MAP4K3, KHS/MAP4K5 and VEGFR; rescues cell survival, mitochondrial function, and calcium cycling in hiPSC-CMs (human induced-pluripotent-stem-cell-derived cardiomyocytes), protects hiPSC-CMs with EC50 of 500 nM for cell death induced by 400 uM H2O2; reduces infarct size and ischemia-reperfusion injury in mice in mice.
In Vitro

DMX-5804 exhibits great selectivity at MAP4K4 over other kinases, such as GCK/MAP4K2 (pIC50, 6.50), GLK/MAP4K3 (pIC50, 4.95), KHS/MAP4K5 (pIC50, 6.36), ABL1 (pIC50, 5.80), Aurora B (pIC50, 5.49), FLT3 (pIC50, 5.31), GSK3β (pIC50, 4.66), MLK1/MAP3K9 (pIC50, 7.19), MLK3/MAP3K11 (pIC50, 6.99), NUAK (pIC50, 6.88) and VEGFR (pIC50, 5.72).
In Vivo

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Synonyms

DMX5804 | DMX 5804
Pathway

MAPK/ERK Signaling
Target

MAP4K
Recptor

MAP4K
Research Area

——
Indication

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CAS Number

2306178-56-1
Formula Weight

361.401
Molecular Formula

C21H19N3O3
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 345.89 mM
SMILES

O=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4
Chemical Name

5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

1. Fiedler LR, et al. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X.

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