dBET6( dBET 6 )

Catalog No. M13051 CAS No. 1950634-92-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

dBET6
Note

Research use only, not for human use.
Brief Description

dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
Description

dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
In Vitro

dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4.
In Vivo

dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL.
Synonyms

dBET 6
Pathway

PROTACs
Target

PROTAC
Recptor

BET
Research Area

——
Indication

——

CAS Number

1950634-92-0
Formula Weight

841.381
Molecular Formula

C42H45ClN8O7S
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
Chemical Name

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-

1. Winter GE, et al. Mol Cell. 2017 Jul 6;67(1):5-18.e19. 2. Cancer Discov. 2017 Aug;7(8):794.

Calculator

molnova catalog