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dBET6
CAS No. 1950634-92-0
dBET6( dBET 6 )
Catalog No. M13051 CAS No. 1950634-92-0
dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 151 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 163 | In Stock |
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| 25MG | 307 | In Stock |
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| 50MG | 482 | In Stock |
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| 100MG | 697 | In Stock |
|
| 200MG | 879 | In Stock |
|
| 500MG | 1283 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamedBET6
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NoteResearch use only, not for human use.
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Brief DescriptiondBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
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DescriptiondBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
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In VitrodBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4.
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In VivodBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL.
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SynonymsdBET 6
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PathwayPROTACs
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TargetPROTAC
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RecptorBET
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Research Area——
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Indication——
Chemical Information
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CAS Number1950634-92-0
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Formula Weight841.381
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Molecular FormulaC42H45ClN8O7S
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
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Chemical Name6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Winter GE, et al. Mol Cell. 2017 Jul 6;67(1):5-18.e19.
2. Cancer Discov. 2017 Aug;7(8):794.
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