FT-001( FT001 )

Catalog No. M12678 CAS No. 1778655-51-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FT-001
Note

Research use only, not for human use.
Brief Description

FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1.
Description

FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1; inhibits the expression of MYC in the MV-4-11 cell line with IC50 of 0.46 uM, shows anti-proliferative activity with IC50 of 0.22 uM; displays complete tumor growth inhibition in mouse MV-4-11 xenograft model.
In Vitro

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In Vivo

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Synonyms

FT001
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

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Indication

——

CAS Number

1778655-51-8
Formula Weight

467.584
Molecular Formula

C25H29N3O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(N1[C@@H](C)CN(C(C2CC2)=O)C3=C1C=CC(C4=CC=C(N(CC5)CCS5(=O)=O)C=C4)=C3)=O
Chemical Name

(S)-1-(4-(cyclopropanecarbonyl)-6-(4-(1,1-dioxidothiomorpholino)phenyl)-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)ethan-1-one

1. Millan DS, et al. ACS Med Chem Lett. 2017 Jul 14;8(8):847-852.

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