Cart
sales@molnova.com
XDM-CBP
CAS No. 2138461-99-9
XDM-CBP( XDM CBP )
Catalog No. M13410 CAS No. 2138461-99-9
A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameXDM-CBP
-
NoteResearch use only, not for human use.
-
Brief DescriptionA highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively.
-
DescriptionA highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family; exhibits antiproliferative effect on numerous cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia (HL-60 and MCF-7 cells GI50=1.3 and 4.2 uM, respectively).
-
In Vitro——
-
In Vivo——
-
SynonymsXDM CBP
-
PathwayChromatin/Epigenetic
-
TargetBromodomain
-
RecptorBromodomain
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2138461-99-9
-
Formula Weight366.417
-
Molecular FormulaC21H22N2O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=C(CC)C(C(C)=O)=C(C)N1)NCC2=C3C(O)=CC=CC3=CC=C2O
-
Chemical Name4-acetyl-N-((2,8-dihydroxynaphthalen-1-yl)methyl)-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hügle M, et al. Angew Chem Int Ed Engl. 2017 Aug 2. doi: 10.1002/anie.201705516.
molnova catalog
related products
-
CPI 0610
CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
-
ZL0454
ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
-
CPI203
CPI 203 (TEN 010, JQ-2, RG-6146) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM.
