RU1968( RU 1968 | RU-1968 )

Catalog No. M12611 CAS No. 171336-24-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

RU1968
Note

Research use only, not for human use.
Brief Description

RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3.
Description

RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3; suppresses progesterone- and prostaglandin-induced Ca2+ signals in human sperm (IC50=4 and 3.8 uM), potently abolishes CatSper-mediated Ca2+ signals in mouse, human, and sea urchin sperm.
In Vitro

——
In Vivo

——
Synonyms

RU 1968 | RU-1968
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel
Research Area

——
Indication

——

CAS Number

171336-24-6
Formula Weight

370.581
Molecular Formula

C24H38N2O
Purity

>98% (HPLC)
Solubility

——
SMILES

OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](C(NCCN(C)C)C)CC[C@@]4([H])[C@]3([H])CCC2=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Chemical Name

(8R,9R,13R,14R,17R)-17-((R)-1-((2-(dimethylamino)ethyl)amino)ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

1. Rennhack A, et al. Br J Pharmacol. 2018 May 3. doi: 10.1111/bph.14355.

Calculator

molnova catalog