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Home - Products - GPCR/G Protein - Calcium Channel - Dantrolene sodium hemiheptahydrate

Dantrolene sodium hemiheptahydrate

CAS No. 24868-20-0

Dantrolene sodium hemiheptahydrate( Dantrolene sodium hydrate )

Catalog No. M13728 CAS No. 24868-20-0

Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Dantrolene sodium hemiheptahydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells.
  • Description
    Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells, inhibits Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
  • In Vitro
    RT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM.Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.
  • In Vivo
    Animal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.
  • Synonyms
    Dantrolene sodium hydrate
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    24868-20-0
  • Formula Weight
    400.3
  • Molecular Formula
    C14H17N4NaO8.5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].O.O.O.O.O.O.O.[Na+].[Na+]
  • Chemical Name
    2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt, hydrate (2:2:7)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zucchi R, et al. Pharmacol Rev. 1997 Mar;49(1):1-51. 2. Barker K, et al. Clin Toxicol (Phila). 2006;44(3):351. 3. Ellis KO, et al. J Pharm Sci. 1973 Jun;62(6):948-51.
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