Dantrolene sodium hemiheptahydrate( Dantrolene sodium hydrate )

Catalog No. M13728 CAS No. 24868-20-0

Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	29	In Stock
100MG	28	In Stock
200MG	Get Quote	In Stock
500MG	82	In Stock
1G	119	In Stock

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Biological Information

Product Name

Dantrolene sodium hemiheptahydrate
Note

Research use only, not for human use.
Brief Description

Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells.
Description

Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells, inhibits Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
In Vitro

RT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM.Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.
In Vivo

Animal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.
Synonyms

Dantrolene sodium hydrate
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Others
Research Area

Other Indications
Indication

——

Chemical Information

CAS Number

24868-20-0
Formula Weight

400.3
Molecular Formula

C14H17N4NaO8.5
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 33 mg/mL
SMILES

C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].O.O.O.O.O.O.O.[Na+].[Na+]
Chemical Name

2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt, hydrate (2:2:7)

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Zucchi R, et al. Pharmacol Rev. 1997 Mar;49(1):1-51. 2. Barker K, et al. Clin Toxicol (Phila). 2006;44(3):351. 3. Ellis KO, et al. J Pharm Sci. 1973 Jun;62(6):948-51.

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