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NP118809

CAS No. 41332-24-5

NP118809( 39-1B4 )

Catalog No. M20746 CAS No. 41332-24-5

NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
10MG 29 In Stock
25MG 40 In Stock
50MG 53 In Stock
100MG 75 In Stock
200MG 91 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NP118809
  • Note
    Research use only, not for human use.
  • Brief Description
    NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
  • Description
    NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
  • In Vitro
    NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM.
  • In Vivo
    NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
  • Synonyms
    39-1B4
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41332-24-5
  • Formula Weight
    460.61
  • Molecular Formula
    C32H32N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (108.55 mM)
  • SMILES
    O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
  • Chemical Name
    1-(4-benzhydrylpiperazin-1-yl)-33-diphenylpropan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zamponi G W Feng Z P Zhang L et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers[J]. Bioorganic & Medicinal Chemistry Letters 2009 19(22):6467-6472.
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