Cart
sales@molnova.com
JTV-519 fumarate
CAS No. 1883549-36-7
JTV-519 fumarate( K201 | JTV519 )
Catalog No. M12934 CAS No. 1883549-36-7
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameJTV-519 fumarate
-
NoteResearch use only, not for human use.
-
Brief DescriptionJTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs).
-
DescriptionJTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively).Heart Arrhythmia Phase 2 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsK201 | JTV519
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1883549-36-7
-
Formula Weight540.675
-
Molecular FormulaC29H36N2O6S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Darcy YL, et al. Mol Pharmacol. 2016 Aug;90(2):106-15.
2. Inagaki K, et al. Circulation. 2000 Feb 22;101(7):797-804.
3. Ito K, et al. Br J Pharmacol. 2000 Jun;130(4):767-76.
4. Nakaya H, et al. Br J Pharmacol. 2000 Dec;131(7):1363-72.
molnova catalog
related products
-
Ionomycin
Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+).
-
GSK-7975A
A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
-
YM-244769 dihydrochl...
YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.
