(S)-Zanubrutinib( S)-Zanubrutinib | BGB3111 | BGB 3111 )

Catalog No. M12579 CAS No. 1691249-45-2

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Product Name

(S)-Zanubrutinib
Note

Research use only, not for human use.
Brief Description

(S)-Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor.
Description

(S)-Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; shows much more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib; demonstrates nanomolar BTK inhibition activity, inhibits BCR aggregation-triggered BTK autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation in several MCL and DLBCL cell lines; demonstrates better anti-tumor activity than ibrutinib in TMD-8 subcutaneous xenograft model.
In Vitro

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In Vivo

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Synonyms

S)-Zanubrutinib | BGB3111 | BGB 3111
Pathway

Tyrosine Kinase
Target

BTK
Recptor

BTK
Research Area

Cancer
Indication

——

CAS Number

1691249-45-2
Formula Weight

471.561
Molecular Formula

C27H29N5O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 56.75 mg/mL 120.35 mM; Ethanol : < 1 mg/mL
SMILES

C=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N
Chemical Name

(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

1. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. AACR.

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