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NE-100 hydrochloride
CAS No. 149409-57-4
NE-100 hydrochloride( NE 100 hydrochloride | NE100 hydrochloride )
Catalog No. M12070 CAS No. 149409-57-4
A potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | In Stock |
|
| 5MG | 76 | In Stock |
|
| 10MG | 125 | In Stock |
|
| 25MG | 210 | In Stock |
|
| 50MG | 312 | In Stock |
|
| 100MG | 464 | In Stock |
|
| 200MG | 662 | In Stock |
|
| 500MG | 981 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNE-100 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM.
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DescriptionA potent, selective, and orally active sigma-1 receptor antagonist with Ki of 1.03 nM; dispalys 205-fold selectivity over sigma-2, 1,000-fold selectivity over D1, D2, PCP, α1, 5-HT1A and 5-HT2 receptors; shows antipsychotic activity in vivo.Schizophrenia Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsNE 100 hydrochloride | NE100 hydrochloride
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PathwayAutophagy
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TargetSigma receptor
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RecptorSigma Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number149409-57-4
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Formula Weight391.97
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Molecular FormulaC23H33NO2.HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (637.80 mM)
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SMILESCOC1=CC=C(CCN(CCC)CCC)C=C1OCCC2=CC=CC=C2.[H]Cl
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Chemical Name4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakazato A, et al. J Med Chem. 1999 Mar 25;42(6):1076-87.
2. Berardi F, et al. Bioorg Med Chem. 2001 May;9(5):1325-35.
3. Ogawa S, et al. Eur J Pharmacol. 1994 Sep 22;263(1-2):9-15.
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