Cart
sales@molnova.com
BMS-919373
CAS No. 1272353-82-8
BMS-919373( BMS919373 )
Catalog No. M11139 CAS No. 1272353-82-8
BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 656 | In Stock |
|
| 5MG | 603 | In Stock |
|
| 10MG | 848 | In Stock |
|
| 25MG | 1254 | In Stock |
|
| 50MG | 1655 | In Stock |
|
| 100MG | 2223 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBMS-919373
-
NoteResearch use only, not for human use.
-
Brief DescriptionBMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
-
DescriptionBMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration; shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.Heart Arrhythmia Phase 1 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsBMS919373
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorPotassium Channel
-
Research AreaCardiovascular Disease
-
IndicationHeart Arrhythmia
Chemical Information
-
CAS Number1272353-82-8
-
Formula Weight468.535
-
Molecular FormulaC25H20N6O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N
-
Chemical Name5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.
molnova catalog
related products
-
VCMMAE
VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
-
Linoleoyl glycine
Linoleoyl glycine, a modified polyunsaturated fatty acid, is an endogenous homologue of linoleoyl glycine. Linoleoyl glycine activates human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in xenopus oocytes from mammalian skin.
-
VU590
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1) that also inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.
