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BMS-919373
CAS No. 1272353-82-8
BMS-919373( BMS919373 )
Catalog No. M11139 CAS No. 1272353-82-8
BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 656 | In Stock |
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| 5MG | 603 | In Stock |
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| 10MG | 848 | In Stock |
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| 25MG | 1254 | In Stock |
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| 50MG | 1655 | In Stock |
|
| 100MG | 2223 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-919373
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
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DescriptionBMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration; shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.Heart Arrhythmia Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsBMS919373
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaCardiovascular Disease
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IndicationHeart Arrhythmia
Chemical Information
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CAS Number1272353-82-8
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Formula Weight468.535
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Molecular FormulaC25H20N6O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N
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Chemical Name5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.
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