Ursodeoxycholic acid

Research use only, not for human use.

Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.

Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.(In Vitro):Ursodeoxycholic acid (10 μM; 24 h) reduces ACE2 and SHP levels in primary airway and intestinal organoids, and reduces SARS-CoV-2 infection in multiple cell types via FXR-mediated ACE2 regulation. (In Vivo):Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) results in weight loss in C57BL/6J wildtype mice.Ursodeoxycholic acid (1% w/w or 416 mg/kg; oral; 7 days) reduces ACE2 expression in mice and hamsters.Ursodeoxycholic acid (416 mg/kg; oral; 7 days) reduces SARS-CoV-2 infection in hamsters.

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Animal Model:5 week old C57BL/6J WT mice (male and female)Dosage:50, 150, and 450 mg/kg dissolved in corn oilAdministration:Oral gavage; daily for 21 daysResult:Mice in the 50 and 450 mg/kg groups sustained significant weight loss within a week. At 50 mg/kg, this weight loss persisted over the course of the experiment. At 450 mg/kg, initially weight loss was noted during the first and third week of ursodiol administration. At 150 mg/kg, it did not have significantly different weights compared to the untreated mice.Animal Model:FVB/N mice and Syrian Golden Hamsters Dosage:1% w/w for mice, 416 mg/kg for hamsters Administration:In chow or oral gavage, 7 days Result:Reduced ACE2 expression.Animal Model:Syrian Golden Hamsters, SARS-CoV-2 infection model Dosage:416 mg/kg Administration:Oral gavage, 7 days Result:Prevented transmission of SARS-CoV-2 in n=6 out of 9 sentinel animals (33% infected vs. 67% uninfected).

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Cell Cycle/DNA Damage

Potassium Channel

Bile salt export pump

Metabolic Disease

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128-13-2

392.57

C24H40O4

>98% (HPLC)

Ethanol: 79 mg/mL (201.23 mM); DMSO: 79 mg/mL (201.23 mM)

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

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(-20℃)

With Ice Pack

≥ 2 years