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PAP-1
CAS No. 870653-45-5
PAP-1( 5-(4-Phenoxybutoxy)psoralen )
Catalog No. M24882 CAS No. 870653-45-5
PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 87 | In Stock |
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| 2MG | 54 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 131 | In Stock |
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| 25MG | 292 | In Stock |
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| 50MG | 509 | In Stock |
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| 100MG | 538 | In Stock |
|
| 200MG | 769 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePAP-1
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NoteResearch use only, not for human use.
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Brief DescriptionPAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
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DescriptionPAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
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In VitroPAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM. Cell Proliferation Assay Cell Line:CCR7-TEM cells (anti-CD3 Ab stimulated)Concentration:2, 10, 25, 100 nM Incubation Time:30 minutes Result:Suppresses the Proliferation of CCR7-TEM cells with IC50 of 10 nM.
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In VivoPAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats. Animal Model:9- to 11- week-old female Lewis rats Dosage:Intraperitoneal injection; three times daily for 48 hours Administration:0.3, 1, 3 mg/kg Result:Dose-dependently suppressed the DTH reaction.
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Synonyms5-(4-Phenoxybutoxy)psoralen
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorKv1.3 channels
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Research Area——
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Indication——
Chemical Information
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CAS Number870653-45-5
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Formula Weight350.36
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Molecular FormulaC21H18O5
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Purity>98% (HPLC)
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SolubilityDMSO:48 mg/mL (137 mM; Need ultrasonic);Water:Insoluble
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SMILESO=C(C=C1)Oc2c1c(OCCCCOc1ccccc1)c(cco1)c1c2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68(5):1254-70.
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