Roy-Bz( PKCδ activator Roy-Bz )

Catalog No. M10997 CAS No. 1246304-91-5

COA

Datasheet

HNMR

HPLC

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Product Name

Roy-Bz
Note

Research use only, not for human use.
Brief Description

Roy-Bz is the first small-molecule PKCδ-selective activator with EC50 of 58.5 nM, binds to the PKCδ-C1-domain.
Description

Roy-Bz is the first small-molecule PKCδ-selective activator with EC50 of 58.5 nM, binds to the PKCδ-C1-domain; displays no activity against human cPKCs (a mix of PKCα, β, and γ), nPKCδ, nPKCε and aPKCζ; potently inhibits the proliferation of colon cancer cells (HCT116 IC50=0.58 uM) by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation; demonstrates PKCδ-dependent antitumor effect, through anti-proliferative, pro-apoptotic, and anti-angiogenic activities in xenograft mouse models with no apparent toxic side effects.
In Vitro

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In Vivo

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Synonyms

PKCδ activator Roy-Bz
Pathway

Angiogenesis
Target

PKC
Recptor

PKC
Research Area

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Indication

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CAS Number

1246304-91-5
Formula Weight

598.692
Molecular Formula

C36H38O8
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(OC1=C(C(C)C)C(C([C@H](OC(C)=O)[C@@H](OC(C2=CC=CC=C2)=O)[C@@H](C(C)(C)CCC3)[C@@]43C)=C4C1=O)=O)C5=CC=CC=C5
Chemical Name

(4bS,8aS,10S)-10-acetoxy-2-isopropyl-4b,8,8-trimethyl-1,4-dioxo-1,4,4b,5,6,7,8,8a,9,10-decahydrophenanthrene-3,9-diyl dibenzoate

1. Bessa C, et al. Cell Death Dis. 2018 Jan 18;9(2):23.

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