Cart
sales@molnova.com
Indolactam V
CAS No. 90365-57-4
Indolactam V( -)-Indolactam V )
Catalog No. M16498 CAS No. 90365-57-4
Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 537 | Get Quote |
|
| 50MG | 2106 | Get Quote |
|
| 100MG | 3186 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameIndolactam V
-
NoteResearch use only, not for human use.
-
Brief DescriptionIndolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC).
-
DescriptionIndolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively; induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of PKC signaling.
-
In Vitro(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity. (-)-Indolactam V shows Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development.
-
In Vivo——
-
Synonyms-)-Indolactam V
-
PathwayAngiogenesis
-
TargetPKC
-
RecptorPKC
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number90365-57-4
-
Formula Weight301.3834
-
Molecular FormulaC17H23N3O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(N[C@H](CO)C1)[C@H](C(C)C)N(C)C2=CC=CC3=C2C1=CN3
-
Chemical Name3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Masuda A, et al. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7.
2. Heikkil? J, et al. Biochem Biophys Res Commun. 1989 Aug 15;162(3):1207-13.
3. Chen S, et al. Nat Chem Biol. 2009 Apr;5(4):258-65.
4. Kazanietz MG, et al. Mol Pharmacol. 1993 Aug;44(2):298-307.
molnova catalog
related products
-
Delcasertib
Delcasertib is a potent and selective inhibitor of δ-protein kinase C (δPKC).
-
Hispidin
Hispidin is a polyphenol originally including antioxidant anti-inflammatory and cytoprotective properties.
-
PKC β pseudosubstrat...
Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
