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Linopirdine
CAS No. 105431-72-9
Linopirdine( DUP-996 | Linopirine )
Catalog No. M10251 CAS No. 105431-72-9
Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 227 | In Stock |
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| 50MG | 384 | In Stock |
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| 100MG | 549 | In Stock |
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| 200MG | 793 | In Stock |
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| 500MG | 1181 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLinopirdine
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NoteResearch use only, not for human use.
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Brief DescriptionLinopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
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DescriptionLinopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.Alzheimer Disease Phase 1 Discontinued.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats (300-350 g)Dosage:0.1, 0.5, 1, 3, 6 mg/kg Administration:5 intravenous bolus injections of increasing dosesResult:Transiently and dose-dependently increases MAP by up to 15%.
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SynonymsDUP-996 | Linopirine
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number105431-72-9
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Formula Weight391.465
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Molecular FormulaC26H21N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (319.32 mM)
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SMILESO=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5
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Chemical Name1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.
2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3.
3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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