Guangxitoxin 1E

Research use only, not for human use.

Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.

Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials. (In Vitro):Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM. In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner.

Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM.In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner.

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Cell Cycle/DNA Damage

Potassium Channel

IC50: 1-3 nM (KV2 channels); 24-54 nM (KV4.3 channels)

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1233152-82-3

3948.61

C178H248N44O45S7

>98% (HPLC)

In Vitro:? H2O : ≥ 1 mg/mL (0.25 mM)

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Sequence:{Glu}{Gly}{Glu}{Cys}{Gly}{Gly}{Phe}{Trp}{Trp}{Lys}{Cys}{Gly}{Ser}{Gly}{Lys}{Pro}{Ala}{Cys}{Cys}{Pro}(Disulfide bridge: Cys4-Cys19; Cys11-Cys24; Cys18-Cys31)

(-20℃)

With Ice Pack

≥ 2 years