Trigonelline hydrochloride

Research use only, not for human use.

Trigonelline hydrochloride is extracted from the seeds of Trigonellafoenum-graecumL.

Trigonelline hydrochloride is extracted from the seeds of Trigonellafoenum-graecumL.(In Vitro):It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H2O2 can induce the necrosis and apoptosis along with H2O2.(In Vivo):Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

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Trigonelline hydrochloride

Cell Cycle/DNA Damage

Potassium Channel

Others

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6138-41-6

173.6

C7H8ClNO2

>98% (HPLC)

DMSO : 6 mg/mL 34.56 mM;

C[n+]1cccc(c1)C(=O)O.[Cl-]

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(-20℃)

With Ice Pack

≥ 2 years