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ML277
CAS No. 1401242-74-7
ML277( CID-53347902 )
Catalog No. M23558 CAS No. 1401242-74-7
ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 77 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 202 | In Stock |
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| 50MG | 299 | In Stock |
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| 100MG | 449 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML277
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NoteResearch use only, not for human use.
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Brief DescriptionML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
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DescriptionML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
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In VitroML277 (1 μM) increases the amplitude of KCNQ1 whole-cell and single-channel currents.
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In Vivo——
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SynonymsCID-53347902
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorKCNQ1
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Research Area——
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Indication——
Chemical Information
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CAS Number1401242-74-7
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Formula Weight471.6
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Molecular FormulaC23H25N3O4S2
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Purity>98% (HPLC)
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SolubilityDMSO:≥60 mg/mL (127.23mM)
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SMILESO=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mattmann ME, Yu H, Lin Z, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22(18):5936-5941. doi:10.1016/j.bmcl.2012.07.060
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