Cart
sales@molnova.com
ML277
CAS No. 1401242-74-7
ML277( CID-53347902 )
Catalog No. M23558 CAS No. 1401242-74-7
ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 77 | In Stock |
|
| 5MG | 67 | In Stock |
|
| 10MG | 112 | In Stock |
|
| 25MG | 202 | In Stock |
|
| 50MG | 299 | In Stock |
|
| 100MG | 449 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML277
-
NoteResearch use only, not for human use.
-
Brief DescriptionML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
-
DescriptionML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
-
In VitroML277 (1 μM) increases the amplitude of KCNQ1 whole-cell and single-channel currents.
-
In Vivo——
-
SynonymsCID-53347902
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorKCNQ1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1401242-74-7
-
Formula Weight471.6
-
Molecular FormulaC23H25N3O4S2
-
Purity>98% (HPLC)
-
SolubilityDMSO:≥60 mg/mL (127.23mM)
-
SMILESO=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Mattmann ME, Yu H, Lin Z, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22(18):5936-5941. doi:10.1016/j.bmcl.2012.07.060
molnova catalog
related products
-
Hexachlorophene
Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.
-
ML402
ML402 is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
-
Almitrine dimesylate
Almitrine dimesylate inhibits selectively the Ca2+-dependent K+ channel and that in rat chemoreceptor cellsused in the treatment of hypoxemic chronic lung diseases.
