SRI 37892( SRI37892 | SRI-37892 )

Catalog No. M10150 CAS No. 1030769-75-5

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Datasheet

HNMR

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Product Name

SRI 37892
Note

Research use only, not for human use.
Brief Description

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.
Description

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay; also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM, demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively; targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling.
In Vitro

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In Vivo

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Synonyms

SRI37892 | SRI-37892
Pathway

Wnt/Notch/Hedgehog
Target

Frizzled
Recptor

Frizzled
Research Area

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Indication

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CAS Number

1030769-75-5
Formula Weight

465.531
Molecular Formula

C26H19N5O2S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NC1=NC(C2=CC3=C(NC(CC3)=O)C=C2)=CS1)C4=CC=C(N5C=NC6=CC=CC=C56)C=C4
Chemical Name

4-(1H-benzo[d]imidazol-1-yl)-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)benzamide

1. Zhang W, et al. Oncotarget. 2017 Sep 6;8(53):91459-91470.

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