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FzM1

CAS No. 1680196-54-6

FzM1( Fzd4 modulator FzM1 | FzM 1 )

Catalog No. M12565 CAS No. 1680196-54-6

A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 53 In Stock
5MG 55 In Stock
10MG 95 In Stock
25MG 188 In Stock
50MG 321 In Stock
100MG 517 In Stock
200MG Get Quote In Stock
500MG 1107 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    FzM1
  • Note
    Research use only, not for human use.
  • Brief Description
    A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.
  • Description
    A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism; induces conformational changes in Fz4 by interacting with the third intracellular loop, ICL3, inhibiting binding of dishevelled (Dsh) and hampering the formation of the Fz4-Dsh complex that is necessary for β-catenin nuclear transport and ultimately transcription of TCF/LEF-regulated genes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Fzd4 modulator FzM1 | FzM 1
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Frizzled
  • Recptor
    Frizzled
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1680196-54-6
  • Formula Weight
    360.43
  • Molecular Formula
    C21H16N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (173.40 mM)
  • SMILES
    O=C(NC1=CC=C2C=CC=CC2=C1)NC3=CC(C4=CC=CS4)=CC(O)=C3
  • Chemical Name
    1-(3-Hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Generoso SF, et al. Nat Chem Biol. 2015 Apr;11(4):280-6. 2. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087.
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