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FzM1.8

CAS No. 2204290-85-5

FzM1.8( FzM 1.8 | Fzd4 agonist FzM1.8 )

Catalog No. M13514 CAS No. 2204290-85-5

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

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Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	91	In Stock
2MG	32	In Stock
5MG	50	In Stock
10MG	80	In Stock
25MG	168	In Stock
50MG	272	In Stock
100MG	425	In Stock
200MG	613	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

FzM1.8
Note

Research use only, not for human use.
Brief Description

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4.
Description

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand; biases FZD4 signaling toward a FZD4/PI3K axis that culminates into transactivation of β-catenin/TCF activity by the histone acetyltransferase CBP/p300; preserves stemness and promotes proliferation of undifferentiated cells.
In Vitro

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In Vivo

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Synonyms

FzM 1.8 | Fzd4 agonist FzM1.8
Pathway

Wnt/Notch/Hedgehog
Target

Frizzled
Recptor

Frizzled
Research Area

——
Indication

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Chemical Information

CAS Number

2204290-85-5
Formula Weight

322.32
Molecular Formula

C18H14N2O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (258.54 mM)
SMILES

O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1
Chemical Name

3-Hydroxy-5-(3-(naphthalen-2-yl)ureido)benzoic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087.

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