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Lifitegrast

CAS No. 1025967-78-5

Lifitegrast ( SAR1118;SAR 1118;SAR-1118 )

Catalog No. M10122 CAS No. 1025967-78-5

A potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells; exhibits good in vitro safety profile and low potency on CYP3A4, CYP2C9 and hERG.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lifitegrast
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells; exhibits good in vitro safety profile and low potency on CYP3A4, CYP2C9 and hERG.
  • Description
    A potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells; exhibits good in vitro safety profile and low potency on CYP3A4, CYP2C9 and hERG; development as an ophthalmic solution for treating dry eye.Other Indication Approved
  • Synonyms
    SAR1118;SAR 1118;SAR-1118
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    LFA-1
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    1025967-78-5
  • Formula Weight
    615.48
  • Molecular Formula
    C29H24Cl2N2O7S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 29 mg/mL
  • SMILES
    O=C(O)[C@@H](NC(C1=C(Cl)C2=C(CN(C(C3=CC=C4C=COC4=C3)=O)CC2)C=C1Cl)=O)CC5=CC=CC(S(=O)(C)=O)=C5
  • Chemical Name
    L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhong M, et al. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6.
2. Sun Y, et al. J Ocul Pharmacol Ther. 2013 May;29(4):395-402.
3. Semba CP, et al. Clin Ophthalmol. 2016 Jun 10;10:1083-94.
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