Valategrast( —— )

Catalog No. M13520 CAS No. 220847-86-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Valategrast
Note

Research use only, not for human use.
Brief Description

Valategrast is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.
Description

Valategrast is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.Asthma Discontinued.
In Vitro

Valategrast contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

220847-86-9
Formula Weight

604.953
Molecular Formula

C30H32Cl3N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 170 mg/mL (281.01 mM)
SMILES

CCN(CC)CCOC(=O)C(CC1=CC=C(C=C1)NC(=O)C2=C(C=CC=C2Cl)Cl)NC(=O)C3=C(C=CC=C3Cl)C
Chemical Name

2-(diethylamino)ethyl (2S)-2-[(2-chloro-6-methylbenzoyl)amino]-3-[4-[(2,6-dichlorobenzoyl)amino]phenyl]propanoate

1. Sidduri A, et al. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2479-82.

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