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BIO-5192

CAS No. 327613-57-0

BIO-5192 ( BIO5192 )

Catalog No. M14065 CAS No. 327613-57-0

A potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BIO-5192
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
  • Description
    A potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM; displays selectively over a range of other integrins (IC50 are 138, 1053, > 500 and > 10,000 nM for α9β1, α2β1, α4β7 and αIIbβ3, respectively); mobilizes hematopoietic stem and progenitor cells (HSPCs) alone or combined with plerixafor (AMD3100).Multiple Sclerosis Discontinued
  • Synonyms
    BIO5192
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    Integrin
  • Research Area
    Inflammation/Immunology
  • Indication
    Multiple Sclerosis

Chemical Information

  • CAS Number
    327613-57-0
  • Formula Weight
    817.78
  • Molecular Formula
    C38H46Cl2N6O8S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1ccccc1NC(=O)Nc2ccc(cc2)CC(=O)N(C)[C@@H](CC(C)C)C(=O)NCC[C@@H](C(=O)O)NC(=O)[C@@H]3CCCN3S(=O)(=O)c4cc(cc(c4)Cl)Cl
  • Chemical Name
    (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Leone DR, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1150-62.
2. Theien BE, et al. Blood. 2003 Dec 15;102(13):4464-71.
3. Ramirez P, et al. Blood. 2009 Aug 13;114(7):1340-3.
4. Bao F, et al. Exp Neurol. 2008 Dec;214(2):160-7.
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