LLY-283 ( LLY283 )

Catalog No. M13171 CAS No. 2040291-27-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LLY-283
Note

Research use only, not for human use.
Brief Description

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
Description

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM; displays excellent against other arginine methyltransferases including the closely related PRMT7 and the type II PRMTs such as PRMT4 and 6; decreases SmBB’-Rme2s levels in MCF7 cells with IC50 of 25 nM, also inhibits the PRMT5 mediated regulation of the splicing of MDM4; inhibits proliferation of A375 cells with IC50 of 45.6 nM; inhibits Tumor growth in mouse xenograft (A375, 20 mg/kg; QD).
Synonyms

LLY283
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

2040291-27-6
Formula Weight

342.36
Molecular Formula

C17H18N4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O[C@H]1[C@H](N2C=CC3=C(N)N=CN=C32)O[C@H]([C@H](O)C4=CC=CC=C4)[C@H]1O
Chemical Name

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol

1. Zahid Q. Bonday, et al. ACS Med. Chem. Lett. 2018. DOI: 10.1021/acsmedchemlett.8b00014.

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