OTS193320 ( OTS-193320;OTS 193320 )

Catalog No. M13286 CAS No. 2093401-33-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

OTS193320
Note

Research use only, not for human use.
Brief Description

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
Description

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM; significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death, attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent; causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM.
Synonyms

OTS-193320;OTS 193320
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

2093401-33-1
Formula Weight

536.03
Molecular Formula

C28H30ClN5O4
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=CC(=C(C=C1C2=CN3C=CC(=CC3=N2)NC4CCC(CC4)NCC5=CC=C(C=C5)[N+](=O)[O-])Cl)OC
Chemical Name

(1s,4s)-N1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N4-(4-nitrobenzyl)cyclohexane-1,4-diamine

1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.

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