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OTS193320
CAS No. 2093401-33-1
OTS193320 ( OTS-193320;OTS 193320 )
Catalog No. M13286 CAS No. 2093401-33-1
OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 284 | Get Quote |
|
| 50MG | 1404 | Get Quote |
|
| 100MG | 2133 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameOTS193320
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NoteResearch use only, not for human use.
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Brief DescriptionOTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
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DescriptionOTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM; significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death, attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent; causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM.
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SynonymsOTS-193320;OTS 193320
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number2093401-33-1
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Formula Weight536.03
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Molecular FormulaC28H30ClN5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCOC1=CC(=C(C=C1C2=CN3C=CC(=CC3=N2)NC4CCC(CC4)NCC5=CC=C(C=C5)[N+](=O)[O-])Cl)OC
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Chemical Name(1s,4s)-N1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N4-(4-nitrobenzyl)cyclohexane-1,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.
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