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UNC1999
CAS No. 1431612-23-5
UNC1999 ( UNC1999; UNC 1999; UNC-1999 )
Catalog No. M11830 CAS No. 1431612-23-5
UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
|
| 5MG | 59 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 168 | In Stock |
|
| 50MG | 272 | In Stock |
|
| 100MG | 489 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUNC1999
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NoteResearch use only, not for human use.
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Brief DescriptionUNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively.
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DescriptionUNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.
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SynonymsUNC1999; UNC 1999; UNC-1999
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorEZH1; EZH2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1431612-23-5
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Formula Weight569.74
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Molecular FormulaC33H43N7O2
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Purity>98%(HPLC)
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SolubilityEthanol: 100 mg/mL (175.51 mM); DMSO: 100 mg/mL (175.51 mM)
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SMILESO=C(NCC1=C(CCC)C=C(C)NC1=O)C2=C3C(N(C(C)C)N=C3)=CC(C4=CC=C(N5CCN(C(C)C)CC5)N=C4)=C2
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Chemical Name1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Konze KD, et al. ACS Chem. Biol. 2013, 8 (6), 1324–1334.
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