UNC1999 ( UNC1999; UNC 1999; UNC-1999 )

Catalog No. M11830 CAS No. 1431612-23-5

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Product Name

UNC1999
Note

Research use only, not for human use.
Brief Description

UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively.
Description

UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.
Synonyms

UNC1999; UNC 1999; UNC-1999
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

EZH1; EZH2
Research Area

Cancer
Indication

——

CAS Number

1431612-23-5
Formula Weight

569.74
Molecular Formula

C33H43N7O2
Purity

>98%(HPLC)
Solubility

Ethanol: 100 mg/mL (175.51 mM); DMSO: 100 mg/mL (175.51 mM)
SMILES

O=C(NCC1=C(CCC)C=C(C)NC1=O)C2=C3C(N(C(C)C)N=C3)=CC(C4=CC=C(N5CCN(C(C)C)CC5)N=C4)=C2
Chemical Name

1-isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide

1.Konze KD, et al. ACS Chem. Biol. 2013, 8 (6), 1324–1334.

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