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LB-205

CAS No. 1113025-86-7

LB-205 ( LB 205;LB205 )

Catalog No. M10416 CAS No. 1113025-86-7

A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    LB-205
  • Note
    Research use only, not for human use.
  • Brief Description
    A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.
  • Description
    A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo; significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA; up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.
  • Synonyms
    LB 205;LB205
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1113025-86-7
  • Formula Weight
    343.45
  • Molecular Formula
    C18H21N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCCCCCC(NC1=CC=CC=C1)=O)C2=CC=CC=C2S
  • Chemical Name
    2-mercapto-N-(6-oxo-6-(pyridin-3-ylamino)hexyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5.
2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52.
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