Corin ( —— )

Catalog No. M12765 CAS No. 1808113-09-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Corin
Note

Research use only, not for human use.
Brief Description

Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex.
Description

Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat; exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes; demonstrates effectivity in slowing tumor growth in a melanoma mouse xenograft model.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1808113-09-8
Formula Weight

428.54
Molecular Formula

C26H28N4O2
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 233.36 mM; H2O : < 0.1 mg/mL
SMILES

C1C(C1N)C2=CC=C(C=C2)NC(=O)CCCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N
Chemical Name

4-(4-((4-(2-aminocyclopropyl)phenyl)amino)-4-oxobutyl)-N-(2-aminophenyl)benzamide

1. Kalin JH, et al. Nat Commun. 2018 Jan 4;9(1):53.

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