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MC-1575
CAS No.
MC-1575 ( MC1575 )
Catalog No. M17051 CAS No.
MC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A.
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameMC-1575
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NoteResearch use only, not for human use.
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Brief DescriptionMC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A.
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DescriptionMC-1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B; exhibits a dose-dependent antiproliferative effect and induces cell cycle arrest although this blockade occurred at a different level than TSA; increases p21(waf1/CIP1) mRNA levels and induces ERbeta gene expression; also suppress IL-8 expression in human melanoma cells.
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SynonymsMC1575
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight329.78
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Molecular FormulaC18H16ClNO3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(E)-3-(3-((E)-3-(3-chlorophenyl)-3-oxoprop-1-en-1-yl)-5-methylcyclopenta-1,3-dien-1-yl)-N-hydroxyacrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53.
2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.
3. Venza I, et al. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.
2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.
3. Venza I, et al. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.
molnova catalog
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