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Home - Research Areas - Cancer - Brain Cancer - LB-100

LB-100

CAS No. 1632032-53-1

LB-100( LB100 )

Catalog No. M12454 CAS No. 1632032-53-1

LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.

LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LB-100
  • Note
    Research use only, not for human use.
  • Brief Description
    LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.
  • Description
    LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM; synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF; significantly enhances tumor growth inhibition by cisplatin in vivo.Brain Cancer Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LB100
  • Pathway
    Cancer
  • Target
    Brain Cancer
  • Recptor
    PP2A
  • Research Area
    Cancer
  • Indication
    Brain Cancer

Chemical Information

  • CAS Number
    1632032-53-1
  • Formula Weight
    268.3089
  • Molecular Formula
    C13H20N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 48 mg/mL; DMSO: < 2.9 mg/mL
  • SMILES
    O=C(C1C(O2)CCC2C1C(N3CCN(C)CC3)=O)O
  • Chemical Name
    7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bai XL, et al. Mol Cancer Ther. 2014 Aug;13(8):2062-72. 2. Chang KE, et al. Mol Cancer Ther. 2015 Jan;14(1):90-100. 3. Gordon IK, et al. Mol Cancer Ther. 2015 Jul;14(7):1540-7.
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    LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.

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